RCN in tampa Messages : 2877-2906 of 2906: digging deep into the old bucket of white racism, and using the politics of fear, hostility and anxiety to win over white voters
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ending war, and deceptions begins will ending fear
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Diet and Pemphigus
In Pursuit of Exogenous Factors in Pemphigus and Fogo Selvagem
Ethel Tur, MD; Sarah Brenner, MD
Individuals with a genetic predisposition to pemphigus will develop the disease only when one
or more additional factors are present. The nature of these factors is as yet unknown, but our
starting point was that certain drugs (penicillamine, captopril, and rifampicin) are recognized
as such factors. Since some nutrients have chemical compositions similar to these known causative
drugs, these nutrients may act similarly and, therefore, nutritional factors should also be suspected.
As when drugs are involved, elimination of the inciting ingredients may be crucial for management
of the disease. This article discusses the possible role of nutritional ingredients in the disease
process of pemphigus, including fruit, leaves, roots, seeds, and even water. Possible causative candidates
are thiol, thiocyanate, phenols, and tannins. Arch Dermatol. 1998;134:1406-1410
Because the variability in the incidence and
age of onset of pemphigus cannot be explained
by genetics, environmental factors
are implied. Susceptibility to autoimmune
diseases is multifactorial1; not all
individuals with a proven susceptible genotype
will develop autoimmunity. In many
diseases, it appears that autoimmunity is
preceded by some environmental insult.
Tissue damage may be the key event that
either allows for release of sequestered antigens
from immunologically privileged
sites or causes local inflammation resulting
in lymphokine release and subsequent
expression of antigens, or both.
Sinha et al1 note that perhaps the biggest
challenge in the future will be the search
for the environmental events that trigger
self-reactivity.
It has been established that exogenous
factors in the form of drugs, in particular
thiol-containing drugs,2,3 play a role
in the induction of pemphigus. This points
to the possibility of finding other offenders,
such as food products with chemical
compositions similar to these drugs.4-9 We
suggest that diet factors are involved in the
pemphigus disease process and that, potentially,
morbidity can be reduced if these
factors are identified and avoided.
DIETARY FACTORS
IN PEMPHIGUS
Thiol
When a thiol group is included in the molecular
structure of a drug, the drug is capable
of inducing pemphigus. Thiol groups
are part of the molecular structure of certain
plants; therefore, when these plants are
ingested, they may have the same effects as
thiol-containing drugs. Indeed, 3 compounds
of garlic (allylmercaptan, allylmethylsulfide,
and allylsulfide) were shown to
induce acantholysis in vitro.5 Garlic belongs
to the Allium group of plants, as do
onion, shallot, chive, and leek, all of which
also contain a thiol group. In the mountainous
(Himalayan) zones of India there are
many wild species of Allium L, and these appear
at tribal markets.10 Evidence for involvement
of thiol-containing foods in autoimmunity
is provided by case reports
indicating induction of pemphigus by garlic7
and leek.6 Elimination of these foods
from the diet induced remission, and readministration
caused exacerbation.
Isothiocyanates (Mustard Oils)
A distinct group of thiol-containing plants
comprises those with thioglucosides—
isothiocyanate-producing glucosides (by
From the Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv
University, Sackler School of Medicine, Tel Aviv, Israel.
ARTICLE
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enzymatic hydrolysis). They are of the mustard family
of plants that includes 3200 species in 375 genera and is
of worldwide distribution.11 Mustard (Brassica nigra) is
a member of the Cruciferae family, as are horseradish,
winter cress, turnip, broccoli (which contains both mustard
oils, namely, isothiocyanates and allyl isothiocyanates),
radish, cabbage, brussel sprouts, and cauliflower.
The seeds of mustard (containing 30% fat) are
used in French mustard, spices, and oils, and seed and
root extracts yield allergenic mustard oils—isothiocyanates.
12 Depending on the chemical structure, the compounds
are immunologically reactive (allyl and benzyl
isothiocyanate) or irritants (phenyl isothiocyanate): they
may either cause antibody-mediated acantholysis or be
incorporated into the epidermis leading to nonimmunologic
biochemical acantholysis in a manner similar to thiolbearing
drugs.13
The caper family (Capparidaceae), a tropical relative
of the mustard family, is another source of thioglucosides.
12 Usually, several thioglucosides coexist in a single
plant, and they are distributed throughout the plant in
varying amounts during its growth cycle. Synthetic oil
of mustard contains allyl isothiocyanate as the principal
ingredient. Allyl isothiocyanate is widely used for flavoring
of food products, especially seasoned sauces. It
is an irritant to mucous membranes and produces blisters
if left in contact with the membranes long enough.14
Phenols
Pemphigus may be topically induced as well: pemphigus
erythematosus has been induced by allergic contact
dermatitis caused by tincture of benzoin,15 and contact
with chromate has also caused pemphigus.16 The possibility
of induction of pemphigus by contact with phenols
has been described.17 Some phenolic compounds such
as phenylisothiocyanate contain sulfur, and others do not.
Following our previous publications,4-9 we received several
letters from patients with pemphigus who experimented
with foods and experienced variations in the
symptoms of their disease with elimination or readministration
of phenol-rich foods.
Urushiol. The mechanism by which urushiol elicits allergic
contact dermatitis probably begins with covalent
binding of the pentadecylcatechols to skin proteins.18 A
similar reaction might be the first step in the sequence
of events leading to acantholysis. Plants containing urushiol
(39,59-pentadecylcatechol) belong to the Anacardiaceae
family that includes the genus Toxicodendron (poison
ivy, poison oak, and poison sumac), the most
prominent genus in causing allergic skin reactions. There
are many related cross-reacting species such as mango,19,20
pistachio, and cashew that belong to the same family.
Other Phenolic Compounds. Aspartame, an artificial
sweetener, is a phenolic compound, as are many other
food additives such as preservatives, colorings, and flavorings.
Sodium benzoate, tartrazine (yellow dye No. 5),
vanillin, eugenol, caffeic acid, vitamins C and E, and cinnamic
acid are all phenols. Cinnamic acid is present in
apple, grape, orange, pineapple, and tomato juices. Cinnamon
spice is derived from the inner bark of Cinnamonium
zeylanicum, the phenol-containing cinnamon tree,
and many other species of Cinnamonium are also used as
spices. Eugenol, for example, an oil distilled from
Cinnamonium green leaves, is used as a flavoring for sweets
and foods.
Pinene, another phenol-containing substance, is used
to flavor baked goods, beverages, candy, condiments,
chewing gum, and ice cream. It is also found in tomatoes,
potatoes, mangoes, and bananas. Phenol-containing
piperine constitutes 5% to 9% of the content of
black pepper. Firewoods used for smoking and grilling
foods are another source of phenol. Ingested phenolics
are secreted in the milk and therefore appear in cows’ milk.
For example, gossypol is a phenolic constituent of cottonseed,
and when cows are fed cottonseed, this fatsoluble
compound appears in all the milk-fat products
made from those cows’ milk. Indole is another phenol
found in milk.
Tannins
Tannins are naturally occurring plant polyphenolic compounds
with considerable biologic activity. The astringency
of many fruits during the early part of growth is
due to high tannin content that declines as the fruit ripens.
Certain woods, root materials, barks, leaves, and even
hairs are also sources of tannin.
Previously, we pointed out the possible role of tannins
in the induction or promotion of pemphigus.8 Some
of the possible effects of tannins are listed below:
Precipitating interaction with proteins Alveolar macrophage stimulation
Interaction with drugs Platelet activation
Effect on nutrition Enzyme inhibition
Release of neutrophil chemotactic factor Metal ion deprivation
There is also evidence suggesting that tannins inhibit copper
utilization.21 Interestingly, the well-known pemphigus
inducer penicillamine is a chelating agent for copper.
Polyphenols induce apoptosis.22 Tannins also induce
binding of IgA paraprotein to red blood cells in a manner
analogous to tanning (waterproofing and preserving
animal skins to make leather) with phenolic plant extracts.
Tannins react with structures on or in the red blood
cell membrane.23 Tannin is frequently used as a crosslinking
agent,24 and similar cross-linkage in the epidermis
may possibly be the mechanism through which these
compounds induce pemphigus. Similarly, the first step
in drug-induced acantholysis involves binding of the drug
to the cell membrane.
Tannic acid has often been used in electron microscopy
as a stain for carbohydrate-rich cell surfaces. Tannic
acid stains the cell surface and intercellular material
in squamous epithelium and the desmosomes.25 Tannins
may activate platelets and are implicated in the
epithelial injury of bronchi by cotton dust. Some are carcinogens,
linked to nasal sinus cancer in woodworkers,
squamous cell carcinoma of the oral mucosa, and gastrointestinal
malignancies. Tannin has been shown to
produce a cytotoxic effect on human peripheral blood
lymphocytes in vitro, although this effect is dependent
on increasing concentrations and time of exposure.26
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Other factors affecting tannin activity include the
steric structure of both the tannin and the protein, absorption,
and the composition and size of the protein on
which the tannins act. Temperature, pH, and the presence
of metal ions, calcium, and other chemical compounds
will also influence tannin activity.
Intake of Tannins. Examples of Foods Containing Tannin.
Cassava (Manihot esculenta Crantz), also known as
manioc, mandioca, Brazilian arrowroot, and yucca, is an
important dietary staple in many forms for more than 500
million people in South America, Africa, and Asia.27 Cassava
roots and leaves contain cyanogenic and noncyanogenic
glycosides. Cassava leaves (both red and white
varieties) also contain condensed tannins. The tannin content
of oven-dried (70°C for 3 days in an air oven) cassava
leaves is from 0.2 to 3 g/100 g, depending on the
variety of cassava, and that of blanched leaves (100°C for
5 minutes) is 0.15 to 0.22 g/100 g.28
Mango also contains high amounts of tannin in the
pulp and skin, though this varies with the different kinds
of mango. India is the largest producer of mango, with
over 60 varieties grown there. The cashew tree produces
apples (not a true fruit botanically) in addition to
the nuts, and these apples are rich in tannins and are used
to make juice and alcoholic drinks in Brazil.
The guarana plant is a perennial climbing shrub
native to Brazil and other wooded Amazon regions. In
recent years, products manufactured from guarana have
been imported into the United States. The fruit is reddish
and contains glossy brown seeds. Some Indian
tribes grate fresh seed and swallow it with water, and
some make a fermented drink. Sometimes it is dry
roasted and then ground with cassava. This mixture of
2 high-tannin foods might have important implications.
The greatest use of guarana presently is as a soft drink,
which is imported to the United States. Guarana contains
a high caffeine level as well as tannin. The total
tannin content of air-dried guarana is 12.1% (proanthocyanidins
and prototannins).29 The seeds before any
treatment contain 6% tannin.
Fruits such as the kola nut, betel nut, black walnut,
raspberry, cherry, cranberry, and blackberry are all
high in tannin content. Avocado, banana, apple, and pear
are also rich in tannins, as are peach, persimmon, eggplant,
and grape skins. Coffee and cocoa seeds and the
roots of ginger, ginseng, and garlic are tannin rich, as are
the leaves of cassava, tea, mate´, and rosemary, the stems
of vanillin, and the shells of carob. Provisions such as beer,
wine, and soft drinks contain tannin additives. Tannin
is also added to candy, ice cream, baked goods, and even
nutritional supplements.
Stimulants and Masticatories. Certain plants that are
used for recreational and social ingestion and also as aphrodisiacs
and medications are rich in tannins (Table 1).
To this category belong the guarana from Brazil, betel nut
or areca nut (Areca catechu) from Malaya, which is popular
in India and in many other countries in that region
and in South Africa, and the kola nut from west Africa.
The appeal of exotic products has led to their spread to
North America as well, where they are now sold in sundries
shops and grocery stores. Guarana and kola nut are
also rich in caffeine and are used as stimulants.30 Chewed
betel nuts release tannins and thiocyanate. Immature nuts
contain 38% to 47% tannin, mainly polymerized leukocyanidins,
but the percentage decreases as the fruit matures,
and processing reduces the level to 8% to 15%.
Betel nut addiction afflicts at least 10% of the human
race.30 The betel quid is a package of fresh betel leaf
(Piper betle vine), the undersurface of which is smeared
with lime, containing pieces of betel nut and tobacco.
Spices are sometimes added too, as well as mustard. The
leaves that are used for chewing contain 1% to 1.3% tannin
and other phenols. The leaf yields 0.62% to 2.4% volatile
oil, which is 75% phenolic.30
The nut itself, aqueous extracts of it, and specific
constituents in the nut can be mutagenic and carcinogenic.
31 Several phenolics from the chewed plant products
can generate free radicals that can exert a cytotoxic
effect on the oral mucosa.32 It is a common practice to
keep pieces of the nut or betel quid in the mouth for prolonged
periods of time. Betel nut constitutes 50% of the
betel quid by weight, and a person may consume the
equivalent of 20 to 30 nuts and 200 leaves of betel vine
per day.
One method of preservation of the fresh betel nuts
involves blanching them in boiling calcium chloride. The
calcium (lime) component of the betel quid may take part
in pemphigus pathogenesis because the reaction of pemphigus
autoantibodies is enhanced by calcium supplementation.
Another ingredient of the betel quid, katha, is derived
from the heartwood of the cutch tree (A catechu),
and contains 11.7% to 14.2% tannin. It is a potent tanning
agent; 0.45 kg of cutch is equal to 3.2 kg to 3.6 kg
of oak bark for tanning purposes. It is also used as an
antioxidant in vegetable oils. An aqueous solution of A
catechu bark containing catechin and tannin, prepared
as a tincture or powder, has been used in the United States
as an astringent coloring in liquors, soft drinks, ice cream,
candy, and baked goods.
The expression of antigens that are markers of epithelial
differentiation may be regulated by substances such
as retinoic acid or calcium. Moreover, these antigens may
be involved in cell-to-cell adhesion in the epidermis.33
Thus, the same food compounds that play a role in car-
Table 1. Tannin and Caffeine Content of Some Masticatories
and Stimulants*
Substance
Tannin
Content
Caffeine
Content
Guarana 12 3-5
Coffee beans 0.7 1-2
Roasted coffee beans 1.7 . . .
Dry tea leaves 3.7 1-4
Kola nuts (Cola nitida, Cola acuminata,
family Sterculiaceae)
3.9-4.4 1.5-3.2
Mate´ 7-11 1.0-1.5
Betel nut (Areca catechu L) 8-15 Negligible
Betel leaf (Piper betle) 1.0-1.3 Negligible
Katha (derived from catechu) 11.7-14.2 Negligible
Cassava leaves 0.15-3.0 Negligible
*Tannin and caffeine contents are measured as a percentage of dry
weight. Ellipses indicate not available.
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cinogenesis of the mouth may play a role in cell-to-cell
adhesion leading to the development of pemphigus. However,
a combination of factors is needed: carcinogenicity
has been shown to occur as a result of chewing a mixture
of pepper leaf, betel, and lime but not the betel nut
without lime.30
Interestingly, chronic exposure to cashew nut oil has
been shown to cause oral carcinoma in women who refrain
from tobacco and betel nut habits.34 In addition, oral
submucous fibrosis, a precancerous condition, is prevalent
among cashew workers in south India.35 Chromosome
breakage observed among betel nut chewers has
been attributed to the joint action of betel nut–derived
alkaloids, polyphenols and/or tannins, and nitrosamines
in the saliva.
Kola nuts (Cola nitida and Cola acuminata, family
Sterculiaceae) were carried to America from Africa with
the slave trade in the 17th century30 and spread due to
the reputation of the seeds as stimulants. Tannin levels
in C nitida are 3.9% to 4.4%, and total polyphenol levels
are 6.7%, particularly catechol and epicatechol. Kola nuts
are consumed fresh wherever they are grown throughout
the world, and aqueous extracts or concentrates are
used as flavorings in soft drinks, particularly with extracts
of coca leaves.
Nuts such as peanuts and pistachios may contribute
to pemphigus induction because people who eat them
have a habit of sucking the shells. These shells have high
tannin content.
Drinks. Tannin is the main component of tea,36 and
coffee also contains a substantial amount of tannin.37 Mate´,
also called yerba mate´, Brazilian tea, or Paraguay tea, is
a tealike beverage popular in many South American countries.
It is brewed from dried leaves of an evergreen tree,
Ilex paraguarensis, and contains caffeine (1%-1.5%) and
tannin (7%-11%). The plant grows wild in southern Brazil,
where pemphigus is endemic in the Parana and Paraguay
river basins.38
Fruit juice, beer, wine, and liquor are all sources of
tannin. Tannins are used in the clarification of wine and
beer. Distilled liquor contains spices and flavoring agents
such as vanillin and cinnamon that contain tannins. But
the most intriguing issue is water. Possible constituents
and effects of water have been discussed in detail in a previous
publication.9 South American pemphigus foliaceus
(endemic pemphigus, fogo selvagem) affects individuals
of all ages and has a familial prevalence where it
is endemic in areas of Brazil. This has prompted a search
for environmental factors.33
Most patients with fogo selvagem live in close proximity
to rivers. Many of these rivers contain high levels
of tannin caused by decomposing leaves and other vegetable
matter from the lush surrounding forests. Along
these rivers, fogo selvagem occurs in regions where the
weather is hot and humid. These conditions are needed
for tannins to decompose, fitting our hypothesis that tannins
in the water are an important factor in pemphigus.
The number of new cases of fogo selvagem is highest
at the end of the rainy season and lowest during the
dry summer. Rainfall causes a rise of the waters; large
quantities of organic materials are then carried by the
stream, and the amount of tannins dissolved in the water
increases. Furthermore, variations of annual rainfall
result in differences in the tannin content, and this may
account for the observation that new fogo selvagem cases
occur in clusters.39
A possible lead toward a means for controlling pemphigus
lies in the fact that chlorination of water results
in the formation of the hypochlorite ion that combines
with phenolic compounds even in high dilutions. This
might account for the disappearance of fogo selvagem following
urbanization, which usually involves treating of
the water.
Spices. Spices have a high tannin content, ranging
from 0.12 g/100 g to 1.26 g/100 g (Table 2). Spices of
the Umbelliferae family (ajowan, coriander, and cumin)
and black pepper have the highest content of tannin. All
over India, where pemphigus is prevalent, spices constitute
an important part of the daily diet.40 Among spices,
red chillies account for the highest daily tannin
consumption by individuals in India, followed by coriander,
cumin seeds, black pepper, and garlic. It is noteworthy
that patients showing positive skin-prick test results
to fresh fruits and vegetables also exhibited positive
skin-prick reactions to spice (mustard included).41
Calcium ions are necessary for the reaction of tannins,
tannins’ action resulting in elevated intracellular calcium
ion concentration. Interestingly, dry ginger, ajowan,
and asafoetida, which are spices with high tannin
content, also have high calcium levels.41
Food coloring. Several food coloring products have
high tannin content. Mangosteen, a tropical fruit that originated
in Southeast Asia, was introduced into the Americas
centuries ago. Its skin contains 13% tannin and is used
Table 2. Tannin and Calcium Content in Spices, and Average Daily Consumption per Individual in India
Spice Tannis, g/100g Calcium, g/100g Spice Consumed, g/d*
Tannins Consumed
in Each Spice, mg/d
Garlic (Allium sativum) 0.12 0.11 2.49 ± 2.78 3.0
Dry ginger (Zingiber officinale) 0.54 1.47 0.04 ± 1.31 0.2
Red chillies (Capsucum annum) 0.90 0.06 3.08 ± 2.06 24.6
Asafortida (Ferula foetida) 0.80 1.01 0.06 ± 0.10 0.5
Coriander (Coriandrum sativum) 0.82 0.65 1.37 ± 1.30 11.3
Cumin seeds (Cuminum cyminum) 0.90 0.92 0.80 ± 0.77 7.2
Black pepper (Piper nigrum) 0.94 0.38 0.33 ± 0.30 3.1
Ajowan (Carum copticum) 1.26 1.26 0.11 ± 0.17 1.4
*Values are expressed as mean ± SD.
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as a coloring for food. The use of the catechu bark as
food coloring was discussed earlier. It is also used as an
antioxidant in vegetable oils.
Nutritional Supplements. Several popular nutritional
supplements contain high concentrations of tannins.
Some preparations are bark extracts containing
proanthocyanidins and other polyphenols. There are
also grape seed extracts containing flavonoids, tea extracts
with high levels of tannins, and mixtures of
extracts with high tannin levels.
CONCLUSIONS
In summary, inferences that diet plays a role in pemphigus
induction may be drawn from a wide variety of facts:
(1) The molecular structure of many food ingredients is
similar to that of known pemphigus-inducing drugs. (2)
Case reports6,7 indicate the connection. (3) Tannins and
phenols are known to interact with proteins. (4) Seasonal
variations in pemphigus incidence coincide with seasonal
tannin variations in diet. (5) Yearly variations in pemphigus
outbreaks coincide with yearly tannin variations.
(6) Incidence of fogo selvagem drops as populations move
into urban areas with chlorinated water supplies.
Finding the exogenous stressors is the first step toward
their elimination. The second step is unfolding the
sequence of events and the interaction between these
stressors. The task is enormous and includes many variables,
as even changes in the mode of preparation of the
same foods might eliminate the deleterious effects of certain
constituents.
We suggest that foods containing thiol, phenolic
compounds, and polyphenols have a role in pemphigus.
But which of the multitude of these compounds are involved,
their mode of action, and under what conditions
their effect is exerted still remains to be unveiled.
Accepted for publication August 17, 1998.
Corresponding author: Ethel Tur, MD, Department of
Dermatology, Ichilov Medical Center, 6 Weizman St, Tel
Aviv, Israel 64239 (e-mail: tur@eng.tau.ac.il).
REFERENCES
1. Sinha AA, Lopez MT, McDevitt HO. Autoimmune diseases: the failure of self tolerance.
Science. 1990;248:1380-1387.
2. Ruocco V, Sacerdoti G. Pemphigus and bullous pemphigoid due to drugs. Int J
Dermatol. 1991;30:307-312.
3. Esposito C, Ruocco V, Cozzolino A, Lo Schiavo A, Lombardi ML, Porta R. Are
acantholysis and transglutaminase inhibition related phenomena? Dermatology.
1996;193:221-225.
4. Brenner S, Wolf R. Possible nutritional factors in induced pemphigus. Dermatology.
1994;189:337-339.
5. Brenner S, Ruocco V, Wolf R, de Angelis E, Lombardi ML. Pemphigus and dietary
factors. Dermatology. 1995;190:197-202.
6. Chorzelski TP, Hashimoto T, Jablonska S, et al. Can pemphigus vulgaris be induced
by nutritional factors? Eur J Dermatol. 1996;6:284-286.
7. Ruocco V, Brenner S, Lombardi ML. A case of diet-related pemphigus. Dermatology.
1996;192:373-374.
8. Tur E, Brenner S. Contributing exogenous factors in pemphigus. Int J Dermatol.
1997;36:888-893.
9. Tur E, Brenner S. The role of the water system as an exogenous factor in pemphigus.
Int J Dermatol. 1997;36:810-816.
10. Negi KS, Pant KC. Less-known wild species of Allium L. (Amaryllidaceae) from
mountainous regions of India. Econ Botany. 1992;46:112-114.
11. Mitchell JC, Jordan WP. Allergic contact dermatitis from the radish, Raphanus
sativus. Br J Dermatol. 1974;91:183-189.
12. Dannaker CJ, White IR. Cutaneous allergy to mustard in a salad maker. Contact
Dermatitis. 1987;16:212-214.
13. Mobini N, Ahmed AR. Immunogenetics of drug-induced bullous diseases. Clin
Dermatol. 1993;11:449-460.
14. Gaul LE. Contact dermatitis from synthetic oil of mustard. Arch Dermatol. 1964;
90:158-159.
15. Lynfield YL, Pertschuk LP, Zimmerman A. Pemphigus erythematosus provoked
by allergic contact dermatitis. Arch Dermatol. 1973;108:690-693.
16. Tsankov N, Stransky L, Kostowa M. Induzierter Pemphigus durch beruflichen
Kontakt mit Basochrom. Dermatosen. 1990;38:91-93.
17. Tsankov N, Dimitrowa J, Obreschkowa E, Lasarowa A. Induziert Pemphigus durch
das Pestizid Phosphamid. Z Hautkr. 1987;62:196-201.
18. Epstein WL. The poison ivy picker of Pennypack Park: the continuing saga of
poison ivy. J Invest Dermatol. 1987;88(suppl):7S-11S.
19. Fisher AA. The notorious poison ivy family of Anacardiaceae plants. Cutis. 1977;
20:570.
20. Catalano PN. Mango sap and poison ivy dermatitis. J Am Acad Dermatol. 1993;
9:522.
21. Kies C, Umoren J. Inhibitors of copper bioutilization: fiber, lead, phytate and tannins.
Adv Exp Med Biol. 1989;258:81-93.
22. Sakagami H, Kuribayashi N, Iida M, et al. Induction of DNA fragmentation by tannin-
and lignin-related substances. Anticancer Res. 1995;15:2121-2128.
23. Hunt AF, Reed MI. Tannic acid and chromic chloride–induced binding of protein
to red cells: a preliminary study of possible binding sites and reaction mechanisms.
Med Lab Sci. 1990;47:189-194.
24. Muzykantov VR, Smirnov MD, Zaltzman AB, Samokhin GP. Tannin-mediated attachment
of avidin provides complement-resistant immunoerythrocytes that can
be lysed in the presence of activator of complement. Anal Biochem. 1993;208:
338-342.
25. Davina JHM, Lamers GEM, van Haelst UJGM, Kenemans P, Stadhouders AM.
Tannic acid binding of cell surfaces in normal, premalignant, and malignant squamous
epithelium of the human uterine cervix. Ultrastruct Pathol. 1984;6:
275-284.
26. Vincentini-Diaz VEP, Takahashi CS. Action of an extract of Stryphnodendron obovatum
Benth seed on rat bone marrow and on human lymphocytes. Rev Bras
Genet. 1993;16:175-185.
27. Okezie BO, Kosikowski FV. Cassava as a food. Crit Rev Food Sci Nutr. 1982;17:
259-275.
28. Awoyinka AF, Abegunde VO, Adewusi SRA. Nutrient content of young cassava
leaves and assessment of their acceptance as a green vegetable in Nigeria. Plant
Foods Hum Nutr. 1995;47:21-28.
29. Marx F. Analysis of guarana seeds, II: studies on the composition of the tannin
fraction. Z Lebensm Unters Forsch. 1990;190:429-431.
30. Morton JF. Widespread tannin intake via stimulants and masticatories, especially
guarana, kola nut, betel vine, and accessories. Basic Life Sci. 1992;59:739-765.
31. van Wyk CW, Stander I, Padayachee A, Grobler-Rabie AF. The areca nut chewing
habit and oral squamous cell carcinoma in South African Indians: a retrospective
study. S Afr Med J. 1993;83:425-429.
32. Stich HF, Mathew B, Sankaranarayanan R, Nair MK. Remission of precancerous
lesions in the oral cavity of tobacco chewers and maintenance of the protective
effect of beta-carotene or vitamin A. Am J Clin Nutr. 1991;53:298S-304S.
33. Sampaio SAP, Rivitti EA, Aoki V, Diaz LA. Brazilian pemphigus foliaceus, endemic
pemphigus foliaceus, or fogo selvagem (wild fire). Dermatol Clin. 1994;
12:765-776.
34. Rajendran R, Anil S, Vijayakumar T. A rare human model for oncogenesis. Singapore
Dent J. 1988;13:49-52.
35. Varghese I, Rajendran R, Sugathan CK, Vijayakumar T. Prevalence of oral submucous
fibrosis among cashew workers of Kerala-south India. Indian J Cancer.
1986;23:101-104.
36. Bokuchava MA, Skobeleva NI. The biochemistry and technology of tea manufacture.
Crit Rev Food Sci Nutr. 1980;12:303-370.
37. Savolainen H. Tannin content of tea and coffee. J Appl Toxicol. 1992;12:191-192.
38. Mate´. In: Encyclopaedia Britannica, Vol 14. Chicago, Ill: William Benton; 1970:
1053.
39. Hans-Filho G, dos Santos V, Katayama JH, et al. An active focus of high prevalence
of fogo selvagem on an Amerindian reservation in Brazil. J Invest Dermatol.
1996;107:68-75.
40. Pradeep KU, Geervani P, Eggum BO. Common Indian spices: nutrient composition,
consumption and contribution to dietary value. Plant Foods Hum Nutr.
1993;44:137-148.
41. Niinimaki A, Hannuksela M, Makinen-Kiljunen S. Skin prick tests and in vitro immunoassays
with native spices and spice extracts. Ann Allergy Asthma Immunol.
1995;75:280-286.
ARCH DERMATOL/VOL 134, NOV 1998
1410
©1998 American Medical Association. All rights reserved.
Downloaded from www.archdermatol.com on January 24, 2012
Food Triggers for Pemphigus | eHow.com: Foods Containing Tannins
Tannins can be found in a variety of foods and beverages. Fruits and vegetables containing tannins that people with pemphigus should avoid are bananas, raspberries, blackberries, apples, pears, cherries, mangoes, cranberries, persimmons, grape skins, avocados and eggplants.
Other tannin triggers are black walnuts, kola nuts, cocoa seeds, black pepper, garlic, ginger, cumin, rosemary, coriander, ginseng, yucca and arrowroot.
Coffee, some teas, soft drinks, beer and wine are among the drinks that contain tannins and could trigger pemphigus.
Foods Containing Isothiocyanates
Isothiocyanates, which are mustard oils found in many types of vegetables, could cause a pemphigus outbreak in people with the disorder. Vegetables in this class are broccoli, cauliflower, cabbage, turnip, mustard, brussel sprouts, winter cress, radish and horseradish.
Some seasoned sauces contain synthetic mustard oils for flavoring, which could irritate mucous membranes in people with pemphigus.
Foods Containing Thiols
Onions, garlic and leeks are thiol-containing foods that can trigger an outbreak or flare-up of pemphigus. These foods are part of the Allium group, which also includes chives and shallots. Foods containing thiols may cause blisters and should be eliminated from the diet if they are suspected as a trigger of pemphigus.
Foods Containing Phenols
Phenols are another trigger for pemphigus and can be found as cinnamic acid in fruit juices and flavorings in ice cream, baked goods, candy, condiments and beverages. Pinene is another common type of phenol that is found in potatoes, tomatoes, bananas, mangoes and black pepper.
Phenols can also be found in foods that are smoked or have a smoked flavor, and in milk and other dairy products from cows that feed on cottonseed.
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PINK FLOYD LYRICS - One Of My Turns: This is just a passing phase
Just one of my bad days
Would you like to watch T. V.?
Or get between the sheets?
Or contemplate the silent freeway?
Would you like something to eat?
Would you like to learn to fly?
Would you like to see me try?
Would you like to call the cops?
Do you think it's time I stopped?
Why are you running away?
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Thank You Jesus Christ for Creating The Way of Your Word!What now?
It's always such a trip. I get filled with the power I AM. Always seeing my life and presence here; getting Tampa on the Map!
And It's Time to Chant
I Love You Dearest Loving Lord Jesus Christ.
Grab a pen and make a list of every time you remember being utterly, happily absorbed in an activity.I feel this way when I do Ritual, when I bike, and whenever I do something that my wife encourages. Of course the last time that I did Ritual, she encouraged me to do that too. It was just awesome of course, with the full moon as well. Now to think about my history of when I get totally "absorbed" and I think about doing some engineering and how it would always totally fill me with passion and desire to complete it all. I now feel like it had more to do with the deadline. It seems whenever I have to get something done "now, or sooner." I remember doing some class assignment and being up late at night or deep into the research and totally loosing track of time.
To predict the next likely step for your inner animal, scan your environment for conditions that seem likely to foster that happy state of absorption, but are just outside your regular routine. Try an activity within that sphere to see if it's a hot track.I think this is an interesting exercise. Yesterday I got all excited writing her in the morning after one of her friends invited us to do something. I had to send the note to her, and then got into writing as well to see if there was more we should plan together or whatever. I told her how much I needed her to support and encourage me, and how adrift I felt with the TV taking too much of our time. I know she gets full of excitement and joy in art, reading and writing deep into some passion she has. I try to encourage this and always remember when we made something with feathers, she was as excited with it as I was. . . and we both created something really cool. I've tried to get her into the garden or into something else like this again . . . but we stopped doing yoga, and haven't biked or bladded together in years, where the TV toke over.
emotions like boredom, hopelessness, anger, or anxiety mean the trail's gone cold.I guess I noticed more how she gets bored. I noticed that is what happens to me as well. I simply get bored with whatever I'm working on. It really annoys me. Like when working in the yard last week. I felt like I had dragged her out to look at what I did, and it was no big deal . . . so I stopped. There is still a big mess out there everywhere - - another half-done project like the million others scattered around the yard where she simply has no interest!
Obvious clear hot tracks such as enjoyment, fascination, or any heartfelt desireI'm not sure where I can find these now? She seemed kinda annoyed with me last night, saying that I was codependent and should not rely on her to find my own peace and power. That seems so backwards and weird. You would think that she would simply encourage me to get rich and famous with some patent or publication so we could hire people to finish our yard work or rebuild the RV or whatever else we want. I mean, if she recognized her power and gave me a clear focus to bring us the success and wealth we need. I mean wouldn't that just be the easiest thing to do!
What do you need to do?I was thinking about how excited I would get speaking to some professors in business and that I needed to go visit them, and see if I could get my clarity and focus again...
2012: Year of Power - Lee Harris - YouTube: For a free mp3 download of this message please visit:
http://www.leeharrisenergy.com/audiogifts.html
For a transcription of the audio, please visit:
http://leeharrisenergy.blogspot.com/2012/01/2012-year-of-power.html
Quick links to video collaborators' websites:
For free monthly energy forecasts, messages and channeling work:
http://LeeHarrisEnergy.com
For more information on how to contact Brad Oliphant and to view his extensive portfolio of his work:
http://BradOliphantPhotography.com
To listen and purchase original muisc creations by Dan Burke:
http://ShiftsMusic.com
* you may download a free mp3 from Dan's website (available from January 3rd)
To watch spiritual videos and discover Oribel's creative work:
http://youtube.com/user/ORIBEL38
http://OribelDivine.com
Peace and Love to all.
Lee, Brad, Dan & Oribel
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Thank You Jesus Christ for Creating The Way of Your Word!What do you think
It IS the year of POWER... what else would 2012 be about ;-)
I Love You Dearest Loving Lord Jesus Christ.
Going Green: 12 Simple Steps for 2012 | Nourishing the Planet: As we head into 2012, many of us will be resolving to lose those few extra pounds, save more money, or spend a few more hours with our families and friends. But there are also some resolutions we can make to make our lives a little greener. Each of us, especially in the United States, can make a commitment to reducing our environmental impacts.
(1) Recycle
(2) Turn off the lights
(3) Make the switch
(4) Turn on the tap
(5) Turn down the heat
(6) Support food recovery programs
(7) Buy local
(8) Get out and ride
(9) Share a car
(10) Plant a garden
(11) Compost
(12) Reduce your meat consumption
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I popped up awake again this morning and felt all this energy moving through me wanting to come out. I saw this message when I first came in here and knew I needed to write more... More about what I need to do this new year. I started thinking of the letters I need to write then also the articles I have written and need to publish. And then I started to think about what they all had in common and what my primary theme might be?
Interesting enough I find myself at the beginning again. Like I've passed through another cycle and come full circle back to my beginning again. The first class I took when I went back to school again was Leadership and Teams. This was when this journal-conversation blog started as well.
Leadership really has a lot to do with who I am and what I am doing. The Earth really has no leader now. No one voice that people respect and listen to, no one worth listening to, and no one saying anything useful either. Course there seems no nations have any worthwhile leaders either. Certainly not this one. We've not had
a real leader since before my birth: November 22, 1963, when JFK died. Interesting: 176 days before I was born, almost 6 months, or 25 weeks, or 4224 hours, 253,440 minutes, or 15,206,400 seconds... numbers are so cool!
Of course, we don't have a sound State leader, while the City leader here might be worth something. The University leader is not. And some College leaders are strong while some are not! I always feel like the real leaders are the ones who lead by doing.
Course I have never been in a better place to do things in my life. I have more freedom and opportunity than I ever thought possible and again find that I am sitting at the calm before the storm, knowing so much more than anyone!!!
I'm reminded now about the crop circles, over 5000 of them, mostly in England, the "leader of the free world" one could say. Course no one there seems to know this, but so much of the culture and ambitions as well as the structures and operations across the world are filled with the influence and words from England. Where else could you go to influence everyone? While the population on the planet is so programmed that to even consider or imply an "outside influence" coming upon the Earth makes you into a crazy person!
Not my problem, I know better. But what's interesting about this is that I do KNOW. Somehow I know we are safe, and I know nothing out there will stop us, or stop me. And I guess I know I can change everything. That's such a funny statement. "Change EVERYTHING!" I always knew this, and it simply is who I am.
Funny, I start writing, then stop to DO something and then write more and stop again. Now I know my focus needs to get back to writing to finding my own voice and getting very specific and detailed about it. Which brings me back to my articles and writing about leadership. There is really so much there for me and so much more for me to write and work on.
What is it?I've been pushing for more focus and clarity every moment. And I'm really feeling good about what i do and say. Like this new article I opened up to when wanting to get online. I new I needed to write and get something out there. The American Machine has run a muck and it's too late to stop it. Thank You Jesus Christ for Creating The Way of Your Word!
What is it?I've not figured out completely. It was like my visitor last week. He knew he needed to make some changes, and knew they had to start deep inside. And the moment he started down this road was the moment he began to feel better. It was great to to speak with him today and hear about him making changes for HIMSELF! Fundamentally being real about his own needs and addressing them.
What is it?I've GOT TO DO THIS more myself... and it's a challenge for me!
8.46pm What is it? Wild thing on pandora and musicI've Thank You Jesus Christ for Creating The Way of Your Word! This music is so awesome and i feel it deep inside at something i can never really express and i know the time is right and it's working fine exactly the way we planned it. And i guess what it really is about doing the same time I've always done. planned, designed, built and changed things all around me. Here again i know that things are coming together.
What is it that you are concerned about is that you are gaining the clarity and focus that you asked for 909pmI've got to finishing packing for our trip tomorrow at 5am,,,,, Thank You Jesus Christ for Creating The Way of Your Word! Fill us with your love and light so we pass in safety and ease through this next quick escape....
starsusaorg: Messages: That fundamental reality would embarrass any university for simply having the structure grant application on the records with such a fundamental error.
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Thank You Jesus Christ for Creating The Way of Your Word!What is so terrifying to me is how dynamic is comes through. pictures and links and words masking the great tapestry. While then I see slight mis perceptions as the grant has concrete and rebar with the pvc, and the flash did not!
I now everything is a lesson, we have to read between the lines. Answers are never abosolute, since there is only one Absolute!
I Love You Dearest Loving Lord Jesus Christ.
Shifting Out of the Matrix: We begin one step, one day at a time. Perhaps we start by setting aside one day each week to "unplug" from electronic devices and to slowly increase this. departure. Or we might limit our plugged in time each day to certain hours and methodically decrease the time.
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what is so funny about this is that we can stop TV, PHONE, RADIO, and MAIL, dropping out of the system and it would go into overload where the IRS, Police etc. could not collect from anyone anymore... the Machine would grind to a halt.
What have you done now?I've gotten back to myself... here with the music and pc and all. My feet are on the desk in front of me with the keyboard in my lap. Sipping coffee and relaxed I'm typing about my life again. . .
What's the next song?"anyway yu want it that's the way you need it , anyway yu want it that's the way you need it, anyway yu want it that's the way you need it, that's the way... any way" Journey
What did you do?I went and clicked through all the songs as they were critical to where i am now
Who else called?I spoke to Sharon as she is at an entrepreneurial event in St Pete - - that I really should be at as well. Then of course the rest of her day is planned about sustainable businesses and green jobs meetings with the city and others. But I need to be writing up my research.
What did you do.I've made breakfast and texted to Kim . . . and was sitting at the desk typing before i remembered to sit back to put up my feet. Now the monitor is over 4 feet away and the text is giant for me to read it.... I realize i can completely set myself up to type a thousand words a minute and i know it is time for me to learn. I did this before and can again really easily if i am ready. of course then i am trying to do too many things at once.
What do you mean?I texted Kim about connecting to the trees she's going to see today with Kathryne. Course now I remember they are going to wineries too, and thought of more I should tell her. lol. it's interesting to stop and think about this as I connect more to my truth, she does again in other ways.
What do you need to do?I told Sharon how she was seeing investors and students who I need to be seeing in a few months. Now I need to write up my research again. And I think about how i wrote before i came to Tampa. And I stop to read what i wrote when i started my phd again now and it's closer to the truth than anything i could think of now. And that's really the power that i have again now. I can simply find and read countless versions of the same story. My life has revolved around this story my whole life. Like the doggie asleep under me now. Of course my lover is going to kiss trees now too. Love and power spinning around onto it self. It's like the movie I saw Tuesday: Thrive. Which is really all about getting back into our power. This awesome Torus of energy spinning out around and then into itself again.
I came in and sat at the one seat left in the front row as the movie was just beginning. Then I soaked into the ground and filled with all the energy before I got centered and chanted "aaaa ooooo". . . soaking up the energy and pumping it through me really strong and clear as Foster spoke about the power of the Torus. Lol... seconds before the end I checked the time 9:27 and ran next door to ask Michael to chant with me ;-) lol...What happened Tuesday night?
What else?It was really cool as I could sense the whole room flowing with me. When I got home I posted to their website another equation code and it was cut off by a big-brother scam. Nothing new for me of course, but this time i wrote their web support team to tell them about it. Course now i think how they are all reading these same words almost as fast as i type them. It's so funny.
What do you mean?I understand how they work and use their own BS to grow and create more and more. It's like Cancer, they pretend to cure it with all this fancy technology and BS; while everything they use actually creates more cancer instead. So the more we struggle with their "cures," the more infected we get. Similarly, the more they try to copy me, analyze it and control it all the more it grows beyond their reach. The system is set up for self destruction, it's simply designed that way, an the more they build and fight to get in control and safe and whatever, the bigger and fast the storm will be to crew them all into dust.
What about specifics?It's like i noticed this blogger update will save a draft of these words I'm writing nearly every minute or less. It almost saves each time i stop writing. What does that mean in techno-terms??? - - basically the words I've typed, or the "0001110011" I arranged on the hard-drive were sent into the universe. Not simply the PC, or the website, or some cookie here or there - - but essentially a gazillion stars within a few light years just got another electron impulse from me!
| Your Love Song Is |
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| Your Power Element is Water |
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